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This was for two reasons

Reduced nicotine-induced release of dopamine in NAc (Nucleus accubens) The nucleus accumbens (NAc), where GLP-1 agonists inhibit nicotine-induced dopamine release, is where smoking behavior is ultimately impacted by GLP-1 receptor activation

155 At the molecular levels astrocytic switch to putrescine catabolism and GABA synthesis is linked to the urea cycle expressed in astrocytes and generally responsible for detoxification of brain ammonium

doi: 10.1089/chi.2022.0062 24 SmathersSAWilsonJGNigroMA

For example, the active agents loaded into liposomes are mixed with a chitosan-glycerophosphate composition